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College of Medicine and Life Sciences Researchers Set Focus to COVID-19

In response to the worldwide outbreak of COVID-19, researchers in The University of Toledo College of Medicine and Life Sciences have swiftly pivoted their focus to projects aimed at thwarting the pandemic.

UToledo scientists are pursuing new treatments, searching for biomarkers that could help physicians better understand disease progression, exploring the body’s immune response to the virus, and investigating the intricacies of the virus itself in hopes of helping build a vaccine.

A research task force led by a pair of veteran medical scientists in the College of Medicine and Life Sciences has been established to foster collaboration and share resources and ideas across the University. More than 100 individuals — including faculty from the UToledo colleges of Pharmacy and Pharmaceutical Sciences, Nursing, Health and Human Services, Natural Sciences and Mathematics, and Engineering — have joined the conversation.

“Our faculty have really stepped forward to tackle the COVID-19 pandemic in a meaningful way,” said Dr. Christopher Cooper, dean of the College of Medicine and Life Sciences. “Ultimately, COVID-19 will be solved by innovative scientists who figure out how we effectively treat and prevent this.”

The UToledo Medical Research Society on April 17 approved $25,000 in funding to each of three projects in the College of Medicine and Life Sciences to jump start research aimed at confronting COVID-19.

Two of those projects are for clinical trials of drugs that might reduce the severity of symptoms.

Dr. Cheryl McCullumsmith, professor and chair of the UToledo Department of Psychiatry and the co-chair of the COVID-19 research task force, is investigating whether fluoxetine, a commonly prescribed antidepressant, might be a novel treatment able to prevent serious complications from COVID-19.

The drug, sold under the brand name Prozac, has previously been shown to block expression of a cell-signaling protein called Interleukin-6 that can trigger an overwhelming immune response called a cytokine storm. In COVID-19, cytokine storms can prove fatal.

“Fluoxetine has extraordinarily strong evidence in its action as a blocker of IL-6 and cytokine storms in both animal models of infection and in human illness such as rheumatoid arthritis and others,” McCullumsmith said. “This project aims to prevent serious outcomes such as hospitalization, respiratory failure and death in people when they are first infected with COVID-19. The goal is to use an existing drug in a new way to prevent serious complications of COVID-19 during the time it will take scientists to develop more lasting solutions, such as vaccines and antiviral treatments.”

In the second project, Dr. Elissar Andari, assistant professor of psychiatry, is moving to test whether oxytocin, a non-steroid hormone known for its role in sociality and attachment, can reduce hyper-inflammation and boost T-cell counts to help the body fight off COVID-19.

“Oxytocin is safe and has been prescribed clinically for more than 50 years,” Andari said. “We believe the mechanisms by which this drug can have a potential is through its known anti-inflammatory effects, as well as through its protective and pro-immune responses. Oxytocin also has known interaction with the ACE2 system, which is the receptor host of the virus.”

Both clinical trials are planned to begin after receiving final approval from the University’s Institutional Review Board.

The third project granted seed funding from the Medical Research Society will go to a project overseen by Dr. Matam Vijay-Kumar, associate professor in the Department of Physiology and Pharmacology.

Vijay-Kumar is investigating flagellin — a bacterial component previously shown to eliminate viral infection — as a possible way to harness innate immune responses to fight the novel coronavirus that causes COVID-19. His project is also aimed at identifying biomarkers that can help clinicians diagnose the early and late stage biomarkers.

“We expect flagellin will serve as an effective therapeutic to restore impaired early anti-viral immune responses, prevent viral entry, and protect against lung and heart damage,” Vijay-Kumar said. “Additionally, we will investigate to what extent DNase I, an enzyme used to treat cystic fibrosis patients, will offer protection against virus-induced lung pathology at late stages.

The Medical Research Society was created in 2014 by a group of community donors to support biomedical research at UToledo. Seed funding from the society has helped provide early data to leverage major grants from nonprofits and federal funding agencies. To date, UToledo faculty have received more than $5.1 million in external funding for projects initially supported by the society.

“It is wonderful to see the engagement of our community leaders who support the Medical Research Society and who have funded three of the projects that are aimed at this scourge,” Cooper said. “This funding will allow our researchers to fast-track these crucial projects.”

Chemical sensing topic of Distinguished University Professor Lecture

Dr. Jon R. Kirchhoff, Distinguished University Professor and Chair of Chemistry and Biochemistry, will discuss his research this week.

The title of his Distinguished University Professor Lecture is “Chemical Sensing: Finding a Needle in a Haystack.” The free, public event will be held Thursday, Feb. 22, at 4 p.m. in Doermann Theatre.

“The presentation will look at the importance of chemical sensing in our everyday lives and the challenges of making accurate and useful measurements,” Kirchhoff said. “Several projects from my research group will be used as examples.”

In his 29th year at The University of Toledo, Kirchhoff has served as associate chair of the Department of Chemistry and Biochemistry for 16 years and chair for four years.

He received his PhD from Purdue University in 1985 and specializes in analytical chemistry focusing on chemical sensing. He has published more than 80 peer-reviewed publications, book chapters and patents, and has been a principal investigator or co-principal investigator on research and infrastructure grants totaling $5.8 million.

Kirchhoff was appointed a Distinguished University Professor in 2010.

“The faculty who have been named Distinguished University Professors are colleagues that I have admired for their significant contributions to the University,” he said. “It is an honor and very humbling to be considered among this group of faculty.”

A reception will follow his lecture in the lobby of University Hall.

UT researchers to lead 38% of Ohio’s new water quality research projects, including ‘impairment’ criteria

The University of Toledo is slated to lead eight out of the 21 new research projects to be funded with $3.5 million from the state of Ohio to address water quality and algal bloom toxicity.

UT, situated on the western basin of Lake Erie, is to receive nearly $1 million of the $3.5 million dedicated by the Ohio Department of Higher Education for these additional projects in the ongoing, statewide Harmful Algal Bloom Research Initiative, which began three years ago after the city of Toledo issued a Do Not Drink advisory for half a million water customers due to the level of microcystin detected in the water.

Dr. Tom Bridgeman, UT algae researcher and professor of ecology, examines a water sample aboard the UT Lake Erie Center research vessel.

UT is one of the lead universities in the Harmful Algal Bloom Research Initiative, which consists of 10 Ohio universities and five state agencies.

The selected projects focus on reducing nutrient loading to Lake Erie; investigating algal toxin formation and human health impacts; studying bloom dynamics; better informing water treatment plants how to remove toxin; and aiding the efforts of state agencies.

Dr. Tom Bridgeman, professor in the Department of Environmental Sciences, will lead a project to develop sampling protocols and collect samples to assess listing criteria that the Ohio Environmental Protection Agency may use to monitor the water quality of the open waters of the western basin of Lake Erie and to potentially assign official designations such as “impaired” or “unimpaired.”

“Although it is obvious to nearly everyone that harmful algal blooms are impairing Lake Erie each summer, we need to develop objective scientific criteria that can be used to list the open waters of the lake as officially ‘impaired,’ and to remove an ‘impairment’ designation in the future if conditions improve sufficiently,” Bridgeman said.

UT researchers also to receive some of the $988,829 in state funding for their projects are:

• Dr. Jason Huntley, associate professor in the Department of Medical Microbiology and Immunology, will be developing and testing biofilters — water filters containing specialized bacteria that degrade microcystin toxins from lake water as it flows through the filter. These biofilter studies are aimed to develop cost-effective, efficient and safe drinking water treatment alternatives for the city of Toledo and other Lake Erie water municipalities.

• Dr. Steven Haller and Dr. David Kennedy, assistant professors in the Department of Medicine, will investigate how cyanotoxins such as microcystin damage organs not only in healthy settings, but in settings that may increase susceptibility such as diabetes, obesity and inflammatory bowel disease. Their research teams are working in concert with experts in medicine, pathology, physiology, pharmacology and chemistry to not only learn how microcystin affects organ function in these settings, but also to create new therapies to prevent and treat organ damage, especially in vulnerable patient populations.

• Dr. Patrick Lawrence, UT professor in the Department of Geography and Planning, will use a transportation model to simulate potential distribution of volume of agricultural manure from permitted livestock facilities to surrounding farmland for application as a nutrient. The results will assist in determining the estimated acreage of land within the Lake Erie western basin where manure application could be undertaken and examine associated crop types, farming practices, soil types, drainage and other environmental conditions in those areas.

• Dr. Saatvika Rai, assistant professor of environmental policy in the Department of Political Science and Public Administration, and Dr. Kevin Czajkowski, professor in the Department of Geography and Planning, will use GIS and remote sensing to assess the implementation of agricultural and farming practices in three sub-watersheds of the Maumee River Basin — Auglaize, Blanchard and St. Joseph — to identify where best management practices are being implemented. These maps will then be correlated with perceptions of farmers through surveys and interviews to identify hotspots and priority areas for policy intervention in the region.

• Dr. April Ames, assistant professor in the College of Health and Human Services, will apply an industrial hygiene technique to the exploration of the presence of microcystin in the air using research boats on Lake Erie. Simultaneously, residents who live on or near Lake Erie will be surveyed about their recreational use and self-reported health.

“I am proud of the work that is being done, and that researchers from our public and private higher education institutions continue to work together to address this issue,” said Ohio Department of Higher Education Chancellor John Carey. “Using the talent of Ohio’s researchers and students to solve pressing problems makes perfect sense.”

The Harmful Algal Bloom Research Initiative is funded by the Ohio Department of Higher Education with $7.1 million made available for four rounds of research funding since 2015. Matching funding from participating Ohio universities increases the total investment to almost $15.5 million for more than 50 projects, demonstrating the state’s overall commitment to solving the harmful algal bloom problem.

Water quality is a major research focus at UT. With more than $14 million in active grants underway, UT experts are studying algal blooms, invasive species such as Asian carp, and pollutants. Researchers are looking for pathways to restore our greatest natural resource for future generations to ensure our communities continue to have access to safe drinking water.

The UT Water Task Force, which is composed of faculty and researchers in diverse fields spanning the University, serves as a resource for government officials and the public looking for expertise on investigating the causes and effects of algal blooms, the health of Lake Erie, and the health of the communities depending on its water. The task force includes experts in economics, engineering, environmental sciences, business, pharmacy, law, chemistry and biochemistry, geography and planning, and medical microbiology and immunology.

Toledo Section of American Chemical Society celebrates 100th anniversary

The Toledo Local Section of the American Chemical Society will celebrate its 100th anniversary Thursday, April 27, with a talk by Barbara Floyd, interim director of University Libraries, on her book “The Glass City: Toledo and the Industry That Built It.”

The book talk, part of the Toledo-Lucas County Public Library’s Open Book Program, will take place at 6 p.m. in McMaster Auditorium of the Toledo main library downtown.

Barbara Floyd will discuss her book, “The Glass City: Toledo and the Industry That Built It,” Thursday, April 27, at 6 p.m. in the Toledo-Lucas County Public Library McMaster Auditorium in downtown.

Floyd’s book, which chronicles the history of Toledo’s most important industry, was published by the University of Michigan Press. It was the winner of the Bowling Green State University’s Center for Archival Collection Local History Publication Award for the best book in the academic scholar category for 2015.

The Toledo Section of the American Chemical Society was founded by members of the UT Department of Chemistry faculty in 1917. The Toledo group is one of 187 local sections of the organization. The society’s mission is “to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and its people.”

According to Joanna Hinton, past chair of the Toledo section, the group will hold events throughout the year in what it is calling its “Chem-tennial 2017.”

The talk at the library will include the presentation of awards to American Chemical Society members for their service.

Floyd, who is also director of the Ward M. Canaday Center for Special Collections, will sign copies of her book, which will be available for sale, after the talk.

For more information on the free, public talk, contact Hinton at 419.346.8876 or visit

Bright work: UT research shines, sets low-bandgap perovskite solar cell world record for efficiency

With the depletion of nonrenewable energy sources and the increase of pollution, researchers have turned to finding ways to harness clean energy from cheap alternative sources.

Researchers at The University of Toledo have recently focused their investigation in the area of perovskite solar cell technology.

Dr. Yanfa Yan and his team make perovskite solar cells in the lab. Their research revealed a world record efficiency (low-bandgap) for the conversion of sunlight to electricity.

Perovskite is a compound material with a special crystal structure, according to Dr. Yanfa Yan, Ohio Research Scholar chair and UT professor of physics.

“Metal halide perovskites can effectively harvest sunlight and efficiently convert it into usable electrical power. They have the potential to be used for fabricating cheap and highly efficient solar cells,” he said. “Perovskite photovoltaic technology has attracted tremendous interest in the past several years.”

Current conventional solar cells are made out of materials such as silicon, a material more expensive than perovskite solar cells.

Yan explained that his research combined theoretical and experimental approaches to understand the fundamental mechanisms of the limitations of the perovskites and to develop processes and design new materials to overcome the limitations.

“Our ultimate goal is to help improve the energy conversion efficiencies of photovoltaic cells and solar fuel devices,” Yan said.

Dr. Yanfa Yan’s all-perovskite tandem solar cell combines two different solar cells to increase the total electrical power generated by using two different parts of the sun’s spectrum.

He and his team did just that. In fact, their research revealed a world record efficiency for the conversion of sunlight to electricity in the area of perovskite solar cell technology using less toxic lead as well as demonstrated a concept for producing an all-perovskite tandem solar cell that can bring together two different solar cells to increase the total electrical power generated by using two different parts of the sun’s spectrum.

“We reported a method that can easily be followed by other researchers in the field,” Yan said.

The research has been published in the journal Nature Energy.

“The publication of this paper in Nature Energy shows a significant recognition of our work by the peers in the field of photovoltaics,” Yan said. “We are very proud of our achievements.”

He added, “We are thankful for collaborations with colleagues in the Wright Center for Photovoltaics Innovation and Commercialization at UT.”

“Dr. Yan and his team are doing outstanding work on this promising type of solar cell, paving the way for cheaper and more efficient ways to provide clean renewable energy to meet the needs of society,” said Dr. Karen Bjorkman, dean of the College of Natural Sciences and Mathematics; Distinguished University Professor of Astronomy; and Helen Luedtke Brooks Endowed Professor of Astronomy. “The faculty and researchers in the Department of Physics and Astronomy and UT’s Wright Center for Photovoltaic Innovation and Commercialization continue to lead the way in improving photovoltaic devices to address our growing energy demands through sustainable and renewable means.”

Patent approved for new spine testing device developed by UT bioengineer

A University of Toledo research professor received a patent for a new device designed to assist with fine-tuning spinal surgeries.

Manoj Kodigudla, research engineer in Dr. Vijay Goel's lab, made adjustments to the spine testing device in the lab.

Manoj Kodigudla, research engineer in Dr. Vijay Goel’s lab, made adjustments to the spine testing device in the lab.

Dr. Vijay Goel, professor of bioengineering and co-director of the Engineering Center for Orthopedic Research Excellence, said the Simplified Spine Testing Device standardizes the range-of-motion testing for pre- and post-surgical procedures.

“The device is used on cadaver samples in the lab to design the surgical process from start to finish,” Goel said. “This standardization greatly reduces the amount of time needed to test range of motion using CT scans and other imaging.”

The patent also was assigned to The University of Toledo, ATS Holdings LLC, the University of Kansas, Norman L. Carroll, Edward C. Cartwright, Robert J. Gephardt, Christopher L. Dixon and Elizabeth A. Friis. The Simplified Spine Testing Device has been licensed to Applied Testing Systems LLC for continued
development and commercialization.

Additionally, Goel and his colleagues Dr. Anand Agarwal and Dr. Sarit Bhaduri, UT professors of bioengineering, founded a spinal biological startup company called OsteoNovus. Goel and Agarwal also founded Spinal Balance, and co-developed other medical devices, including the Libra Pedicle Screw System. The pre-sterilized, individually packaged screw system was designed to reduce the risk of surgical infection for spine surgery patients.

UT doctoral student honored for identifying how climate change threatens food quality

A doctoral student at The University of Toledo recently won an award from the Ecological Society of America for his study that shows why the combination of high carbon dioxide levels in the air and chronic global warming will contribute to a decrease in crop production and food quality during the next few decades.



“We have provided a better understanding of what scientists need to do to improve the heat tolerance of crops in the future,” said Dileepa Jayawardena, a PhD student in the Department of Environmental Sciences, who conducted the climate change study as a project for his master’s degree. “They can use this information to generate new climate-change-tolerant crops to help feed the growing human population.”

Using tomato as a model, Jayawardena investigated the way plants absorb nitrogen fertilizer from the soil.

Over the course of 18 days inside controlled growth chambers in Bowman-Oddy Laboratories, the plants were subjected to conditions that mimic future climate by Jayawardena’s team.

Individually, elevated carbon dioxide and warming did not have large effects on tomato responses.

However, when combined, researchers saw a large decrease in the uptake rate of soil nitrate and ammonium through the roots. At the same time, researchers saw a significant drop in the concentration and function of the proteins that roots use to acquire soil nitrogen. The result was a crop with lower nitrogen levels and thus lower nutritional value.

Dileepa Jayawardena grew tomato in a controlled environment to mimic future climate change and assessed the plants’ growth.

Dileepa Jayawardena grew tomato in a controlled environment to mimic future climate change and assessed the plants’ growth.

Jayawardena’s work also shows that the combination of heat and carbon dioxide is bad for the plant in terms of being able to convert inorganic nitrogen, like nitrate and ammonium, into organic form, like protein, which is the form of nitrogen that humans require.

“If climate change intensifies, this impact on plant nitrogen concentration means that plants will not grow as big in the future, and they will be poorer-quality food for people and other animals that eat plants,” he said.

Jayawardena won the New Phytologist Poster Award for his presentation at the Ecological Society of America annual meeting last month in Florida. It is the nation’s largest organization of professional ecologists with a membership of more than 10,000 scientists.

“By itself, increases in atmospheric carbon dioxide levels tend to increase plant growth, which is a positive,” said Dr. Scott Heckathorn, UT ecology professor and Jayawardena’s faculty advisor. “However, increasing carbon dioxide is the primary cause of current global warming, which will increase heat stress for much life on the planet. The question then arises as to whether benefits of elevated carbon dioxide will offset the negative effects of increasing heat stress. What is new about Dileepa’s work is that it provides a mechanism for why the combination of elevated carbon dioxide and heat is detrimental.”

The research was funded by the U.S. Department of Agriculture.

Photography book frames Toledo’s past to highlight present

Guts — that’s what Ben Morales needed to get some of the photos for Hindsight: Northwest Ohio Through the Lens of Time.

There’s a shot of the Glass City’s iconic Anthony Wayne Bridge.

Hindsight-cover“Traffic never seems to slow on that bridge, and I had to walk out to the median. There really isn’t a place to stand; I had to straddle the cement median as traffic was whizzing by close to me,” he recalled.

And the Capital Tire & Rubber Co. building at the corner of Cherry Street and Spielbusch Avenue in downtown Toledo.

“I tried several times to get the photo, but I could never bring myself to walk out into the intersection because there was always traffic. And finally on my fourth or fifth attempt, I just went out and had some cars honking at me, and it was quite terrifying. And when I was leaving the intersection, I dropped my keys, so I had to run out there again and get them. 

“It literally only took me 10 seconds to get the shot. It probably took me 10 minutes to get the courage to walk out there,” Morales said and laughed.

He waded into the cold, rushing Maumee River for a photo of Roche de Boeuf and Interurban Bridge in Waterville. 

UT’s University Hall is one of nearly 100 locations featured in Ben Morales’ "Hindsight: Northwest Ohio Through the Lens of Time."

UT’s University Hall is one of nearly 100 locations featured in Ben Morales’ “Hindsight: Northwest Ohio Through the Lens of Time.”

“Thankfully, my friend loaned me waders,” Morales said. “I needed to go into the river for the correct alignment for that shot.”

Perspective is critical for Hindsight, which features historical black-and-white photos that Morales held and lined up in front of the same locations to take new seamless shots that meld time.

It all started four years ago when the graphic designer was working at a local ad agency and was looking for inspiration for the “You Are Here Toledo” project. He searched for an old photo of the Washington Street Bridge.

“I found a really nice old shot of the bridge and, along with that, I found a lot of old shots of the Toledo area that I’d never seen before,” Morales said. “I was just kind of amazed by the richness of Toledo’s history and how interesting it looks and how different it looks, but at the same time, we could still see a glimpse of that today that I hadn’t really taken notice of until then.”

Something compelled him to print out a couple of the black-and-white shots. He cut out the images of the former Key Bank on Madison Avenue and a shot looking down Madison and tucked them into his pocket. 

Mancy's Steakhouse on Phillips Avenue

Mancy’s Steakhouse on Phillips Avenue

“On my lunch break, I was just walking around downtown and thought it would be cool to go to the actual locations and compare and contrast — look at the photo compared to how it looked in real life,” he said. “So I took the opportunity to walk to those locations and do my best to line them up, and I took my first shots with my old iPhone 4.”

Then he posted the photo of the old-timey snapshot framed in the present on Instagram.

“The photos got a really resounding response, and people suggested more locations,” Morales said. “I thought it would be interesting to try to see if I could find more of these photos and continue it as a series.”

Arjun Sabharwal, associate professor and digital initiatives librarian in Carlson Library, was a fan of Morales’ work on Toledo Rephotography on Instagram at #toledorephotography.

Morales book signing box“What is particularly compelling is how Ben’s work combines new technology with history,” Sabharwal said. “The time, effort and imagination lends his book seriousness, credibility and originality.”

A history buff who helps manage Toledo’s Attic website, Sabharwal recalled three years ago when northwest Ohio’s virtual museum invited the public to contribute Instagram shots tagged #toledosattic: “By the time the contributions exceeded 2,000 images, the experiment had morphed into a publicly curated exhibition representing local history through the public eye. Ben’s work was truly a gem from the outset.”

He mentioned Morales’ cool project to Barbara Floyd, interim director of University Libraries and director of the UT Press.

Toledo, Lake Erie and Western Railroad Bridge over the Maumee River

Toledo, Lake Erie and Western Railroad Bridge over the Maumee River

“I felt that Ben’s photography was so original in concept that it deserved a larger audience,” Floyd, director of the Ward M. Canaday Center for Special Collections, said. “And because his work is focused on images from northwest Ohio, it seemed like a perfect fit with the mission of the UT Press. We have found that photography books featuring local images are very popular, such as the book of photographs of rock and blues stars performing in Toledo taken by John Rockwood that we published last year.”

Floyd added, “I love the way you can almost walk into history through Ben’s photos.”

Photos and historical information on The University of Toledo, Ohio Theatre, Toledo Zoo, Holy Rosary Cathedral, Oliver House, Toledo Museum of Art, Side Cut Metropark, and other landmarks are included in the 145-page book.

“The Valentine Theatre, particularly with Houdini hanging from the top of the façade, is probably my favorite photo because I love Houdini and it fascinates me that he was even in Toledo let alone hanging by a chain with a straitjacket on,” Morales said.

That stunning shot also is a favorite of Yarko Kuk, managing editor of the UT Press, who helped track down historical information included in the book and arranged access for Morales to take some photos.

“Ben went to great lengths to create thoughtful then and now photographs,” Kuk said. “We really tried to capture the sense of a bygone era and the history that surrounds us.”

“There’s just something about old photos — there’s just sort of a haunting beauty behind them,” Morales mused.

Hindsight: Northwest Ohio Through the Lens of Time is $39.95 and available online at, as well as at Rockets Bookstore, 3047 W. Bancroft St., and Gathering Volumes, 196 E. South Boundary St., Perrysburg.

“The past is all around us, but we don’t always notice it because it is often tucked away in between modern structures, and it may not be quite as visible as it once was,” Morales said. “I want people to be able to see, notice and appreciate the beauty of the past and take ownership of it.”

UT researchers receive funding to study link between kidney disorder and cardiovascular disease

Researchers at The University of Toledo are examining how a genetic kidney disorder also increases the person’s risk of cardiovascular disease and stroke.

Dr. Wissam AbouAlaiwi, assistant professor in the Department of Pharmacology and Experimental Therapeutics, received a three-year, $231,000 Scientist Development Grant, and doctoral student Hannah Saternos received a $2,000 award from the American Heart Association to study the pathophysiology of cardiovascular disease in polycystic kidney disease (PKD).

Dr. Wissam AbouAlaiwi and doctoral student Hannah Saternos both received grants for their research examining how a genetic kidney disorder increases a person’s risk of cardiovascular disease and stroke.

Dr. Wissam AbouAlaiwi and doctoral student Hannah Saternos both received grants for their research examining how a genetic kidney disorder increases a person’s risk of cardiovascular disease and stroke.

PKD is a genetic disorder that causes numerous fluid-filled cysts to grow in the kidneys, ultimately destroying their architecture and reducing their function over time. These cysts also are associated with the development of high blood pressure and problems with the heart and blood vessels in the brain.

“There is currently no cure or treatment for PKD. A kidney transplant can buy an individual more time, but patients with PKD will still usually die from cardiovascular complications such as high blood pressure and heart disease,” AbouAlaiwi said.

AbouAlaiwi and his team are studying a cellular organelle called primary cilia and its role in kidney and cardiovascular disease.

“Primary cilia are antenna-like structures that, until recently, were believed to have no function in the body. We now know they contribute to dozens of genetic disorders and play a role in calcium signaling in heart cells, which is important to its contraction,” he said. “We have developed mouse models to further study these cilia and the complications that arise from their dysfunction.”

This is the third grant for AbouAlaiwi’s lab in one year, and he is quick to credit his team of students for their hard work and dedication.

“The students are very reliable and passionate and the driving force behind the research,” he said. “Funding for research is very competitive, and I am proud that Hannah was able to receive support from the American Heart Association. She is very talented, smart and dedicated to her work. The award is well-deserved.”

Saternos is researching the function of a family of receptors that she recently discovered in the primary cilia and how it affects PKD and regulates blood pressure.

“If you would have told me four years ago I would be working with the kidney and loving it, I would have thought you were crazy,” she said. “It’s fascinating. I don’t think people realize how much impact the kidney has on the rest of the body.”

Researchers awarded grant to study how to increase diversity in engineering workforce

The National Science Foundation awarded $123,859 to a team of researchers at The University of Toledo to study the factors affecting the success and career choices of underrepresented minority engineering students.

The two-year project will compare factors at UT and Alabama Agricultural and Mechanical University.

Business Hlogo 1c BlackThe study will focus on the attitudes and beliefs of faculty and staff, existing institutional support mechanisms, and the role of student organizations. The research will examine the effects these have on the social and academic integration of African-American students.

“The broader impact of this project is that it addresses the national need to diversify the engineering workforce,” said Dr. Lesley Berhan, the project’s principal investigator and associate professor in the Department of Mechanical, Industrial and Manufacturing Engineering. “The results will be used to identify areas where existing practices might be improved and to inform the design of programs and intervention strategies to improve the success of underrepresented engineering students not only at our home institutions, but at institutions across the country.”

Berhan will work with Dr. Revathy Kumar, professor of educational psychology, and Dr. Willie McKether, vice president for diversity and inclusion, on the project titled “Factors Affecting Underrepresented Minority Student Success and Pathways to Engineering Careers at Majority and Minority Institutions.”

According to the National Science Foundation project summary, “While inadequate college preparation is a contributing factor in the low enrollment and poor retention and graduation rates among underrepresented students in engineering programs, there is evidence that professional persistence is directly linked to identity development and social and academic interactions.”

“Once again, The University of Toledo is on the forefront of cross-cutting, long-term research that will determine our economic destiny,” Congresswoman Marcy Kaptur said. “It’s important for future generations and our economic standing to understand and develop the means to maximize opportunity for all of our citizens to contribute to their best God-given abilities. This research aims to do that.”