![\"\"](\"http:\/\/news.utoledo.edu\/wp-content\/uploads\/2018\/04\/AbouAlaiwi-in-the-lab.jpg\")
<\/a>AbouAlaiwi<\/p><\/div>\u201cWe want to stimulate students\u2019 interest in research, so they stay in the biomedical research field and become research scientists,\u201d AbouAlaiwi said.<\/p>\n
His students already are receiving attention for their research, which was published in the October issue of the online Nature journal Scientific Reports.<\/p>\n
AbouAlaiwi and his students\u2019 research in the UT Department of Pharmacology and Experimental Therapeutics focuses on cilia. The motile type of cilia is important because they help move fluids throughout the body and nourish brain cells. Non-motile cilia function as sensors, triggering biochemical processes within the body.<\/p>\n
The team of students that recently published their work studied how alcohol affects the function of cilia in the brain. The paper\u2019s lead author was Alzahra J. Al Omran, a graduate student in pharmacology and toxicology track. She will be continuing her studies as a PhD student in the fall, studying pharmacology and experimental therapeutics in AbouAlaiwi\u2019s laboratory. The team also included graduate students Hannah C. Saternos, Alexander Wisner and Yusuff Althobaiti. <\/p>\n
Their research explored whether cilia in brain cells play a part in some of the first symptoms \u2014 headaches and confusion \u2014 experienced by someone who abuses alcohol. <\/p>\n
Scientists already knew that malfunctioning cilia play a part in many genetic diseases. For instance, if cilia in the brain don\u2019t do their job \u2014 to help circulate cerebral spinal fluid \u2014 fluid can build up in the brain in a condition known as hydrocephalus. <\/p>\n
The UT team wondered whether malfunctioning cilia have anything to do with the symptoms of alcohol abuse. To figure this out, they needed to study the beating frequency of the cilia.<\/p>\n
It was their method in doing this, as much as their results, that attracted the journal\u2019s attention, AbouAlaiwi said.<\/p>\n
In the past, scientists were not able to determine the exact effect on the beating frequency of cilia because they were looking at the organelles in cells, not in live animals.<\/p>\n
UT researchers were able to see the cilia in action. They served up alcohol to rats and within a half hour, isolated their brains using a technique developed in their lab. They examined cilia while they were still beating in the brain and ascertained how frequently they beat. <\/p>\n
The results didn\u2019t surprise researchers: Alcohol significantly slows down the cilia and hampers its ability to mobilize fluids. This dysfunction could affect brain cell function and may contribute to headaches and confusion that accompany alcohol abuse.<\/p>\n
In another first, the UT team discovered three kinds of cilia in brain ventricles. Each has a unique beating frequency and angle. Each also tends to congregate in a certain part of the brain ventricle \u2014 one kind at the ends and two others along the edges. <\/p>\n
AbouAlaiwi said the research is still in its early stages. More research is needed on the characteristics of each kind of cilia and why they are distributed the way they are. But the more they can unearth about the cilia\u2019s behavior in the future, the greater chance of developing drugs to repair the malfunctioning cilia and restore their beating frequency. <\/p>\n
\u201cWe\u2019re starting to explore cilia-based therapy,\u201d AbouAlaiwi said. \u201cIf we can find drugs to specifically target cilia, we could one day find cures for these genetic diseases.\u201d<\/p>\n
The NIH grant also will support AbouAlaiwi\u2019s ongoing research suggesting that the cardiovascular symptoms of patients with polycystic kidney disease may be caused by malfunctioning or mutated cilia.<\/p>\n
AbouAlaiwi, in research that hasn\u2019t been published yet, discovered a family of receptors found in primary cilia, the kind of cilia that act as sensors to transform signals into active biochemical processes in the body. It was the first proof scientists had that cilia house this family of receptors.<\/p>\n
Receptors have been the primary focus of research on neurodegenerative disease, AbouAlaiwi said. He\u2019s now studying whether the receptors have anything to do with polycystic kidney disease and hypertension.<\/p>\n","protected":false},"excerpt":{"rendered":"
Dr. Wissam AbouAlaiwi has received a $400,000 National Institutes of Health grant to continue studying cilia.<\/p>\n","protected":false},"author":837,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,42,3,7],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/posts\/49541"}],"collection":[{"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/users\/837"}],"replies":[{"embeddable":true,"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/comments?post=49541"}],"version-history":[{"count":3,"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/posts\/49541\/revisions"}],"predecessor-version":[{"id":49630,"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/posts\/49541\/revisions\/49630"}],"wp:attachment":[{"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/media?parent=49541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/categories?post=49541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.utoledo.edu\/index.php\/wp-json\/wp\/v2\/tags?post=49541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}